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cd8a knockout (ko) mice  (Technology Development Co)

 
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    Technology Development Co cd8a knockout (ko) mice
    <t>CD8</t> + T-cell deletion mitigated the CaCl 2 -induced AAA formation and the investigated protein levels in aortic tissues. A,B: Representative photographs and data of the maximal external aortic diameter in CD8 +/+ and CD8 −/− mice treated with NaCl or CaCl 2 , respectively (n = 8/group). C–F: Representative western blotting images and quantitative data for the levels of NLRP3, caspase-1, gp91 phox , collagen I, and collagen III proteins in four experimental groups (n = 4/group). G,H: The ELISA results showing the serum levels of IFN-γ and IL-1β in the four groups (n = 6/group).
    Cd8a Knockout (Ko) Mice, supplied by Technology Development Co, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/cd8a knockout (ko) mice/product/Technology Development Co
    Average 90 stars, based on 1 article reviews
    cd8a knockout (ko) mice - by Bioz Stars, 2026-06
    90/100 stars

    Images

    1) Product Images from "CD8 + T-cell deficiency protects mice from abdominal aortic aneurysm formation in response to calcium chloride 2"

    Article Title: CD8 + T-cell deficiency protects mice from abdominal aortic aneurysm formation in response to calcium chloride 2

    Journal: Journal of Hypertension

    doi: 10.1097/HJH.0000000000003823

    CD8 + T-cell deletion mitigated the CaCl 2 -induced AAA formation and the investigated protein levels in aortic tissues. A,B: Representative photographs and data of the maximal external aortic diameter in CD8 +/+ and CD8 −/− mice treated with NaCl or CaCl 2 , respectively (n = 8/group). C–F: Representative western blotting images and quantitative data for the levels of NLRP3, caspase-1, gp91 phox , collagen I, and collagen III proteins in four experimental groups (n = 4/group). G,H: The ELISA results showing the serum levels of IFN-γ and IL-1β in the four groups (n = 6/group).
    Figure Legend Snippet: CD8 + T-cell deletion mitigated the CaCl 2 -induced AAA formation and the investigated protein levels in aortic tissues. A,B: Representative photographs and data of the maximal external aortic diameter in CD8 +/+ and CD8 −/− mice treated with NaCl or CaCl 2 , respectively (n = 8/group). C–F: Representative western blotting images and quantitative data for the levels of NLRP3, caspase-1, gp91 phox , collagen I, and collagen III proteins in four experimental groups (n = 4/group). G,H: The ELISA results showing the serum levels of IFN-γ and IL-1β in the four groups (n = 6/group).

    Techniques Used: Western Blot, Enzyme-linked Immunosorbent Assay

    CD8 + T-cell deficiency alleviated the histopathological changes and recruitment of inflammatory cells. A: The histopathological analysis (H&E, EVG, and Masson trichrome staining) of abdominal aortas of CD8 +/+ and CD8 −/− mice treated with NaCl or CaCl 2 , respectively. Scale bar: upper layer 100 μm, lower layer 50 μm. B: Quantification of the collagen deposition area of the abdominal aortas (n = 5/group). C: Quantification of the elastin degradation score of the abdominal aortas (n = 5/group). D-F: Representative images of IFN-γ + /CD8a + T cell and MMP-2 + / and MMP-9 + /CD68 + macrophage in the adventitia of CD8 +/+ and CD8 −/− AAA mice (n = 5/group). Scale bar: 50 μm. L, Lumen.
    Figure Legend Snippet: CD8 + T-cell deficiency alleviated the histopathological changes and recruitment of inflammatory cells. A: The histopathological analysis (H&E, EVG, and Masson trichrome staining) of abdominal aortas of CD8 +/+ and CD8 −/− mice treated with NaCl or CaCl 2 , respectively. Scale bar: upper layer 100 μm, lower layer 50 μm. B: Quantification of the collagen deposition area of the abdominal aortas (n = 5/group). C: Quantification of the elastin degradation score of the abdominal aortas (n = 5/group). D-F: Representative images of IFN-γ + /CD8a + T cell and MMP-2 + / and MMP-9 + /CD68 + macrophage in the adventitia of CD8 +/+ and CD8 −/− AAA mice (n = 5/group). Scale bar: 50 μm. L, Lumen.

    Techniques Used: Staining

    IFN-γ loading accelerated the CaCl 2 -induced AAA formation in the CD8 −/− mice. A,B: Representative photographs and quantitative data of the maximal external aortic diameter in the PBS-injected (Vehicle) or IFN-γ-injected CD8 −/− mice after CaCl 2 aneurysm induction (n = 8/group). C,D: Representative immunoblotting images and quantitative data for the levels of NLRP3, caspase-1, gp91 phox , collagen I, and collagen III proteins in the two groups (n = 3/group). E: The ELISA results showing the serum levels of IL-1β in both groups (n = 6/group).
    Figure Legend Snippet: IFN-γ loading accelerated the CaCl 2 -induced AAA formation in the CD8 −/− mice. A,B: Representative photographs and quantitative data of the maximal external aortic diameter in the PBS-injected (Vehicle) or IFN-γ-injected CD8 −/− mice after CaCl 2 aneurysm induction (n = 8/group). C,D: Representative immunoblotting images and quantitative data for the levels of NLRP3, caspase-1, gp91 phox , collagen I, and collagen III proteins in the two groups (n = 3/group). E: The ELISA results showing the serum levels of IL-1β in both groups (n = 6/group).

    Techniques Used: Injection, Western Blot, Enzyme-linked Immunosorbent Assay

    IFN-γ accelerated the histopathological changes and the recruitment of inflammatory cells in the CaCl 2 -induced AAAs in the CD8 −/− mice. A: The histopathological analysis (H&E, EVG, and Masson trichrome staining) of abdominal aortas of PBS-injected (Vehicle) and IFN-γ-injected CD8 −/− mice after CaCl 2 aneurysm induction. Scale bar: upper layer 100 μm, lower layer 50 μm. B: Quantification of the collagen deposition area of the abdominal aortas (n = 5/group). C: Quantification of the elastin degradation score of the abdominal aortas (n = 6/group). D-F: Representative images of IFN-γ + /CD8a + T cell and MMP-2 + / and MMP-9 + /CD68 + macrophage in the adventitia of CD8 −/− AAA mice treated with PBS and IFN-γ (n = 5/group). Scale bar: 50 μm. L, lumen.
    Figure Legend Snippet: IFN-γ accelerated the histopathological changes and the recruitment of inflammatory cells in the CaCl 2 -induced AAAs in the CD8 −/− mice. A: The histopathological analysis (H&E, EVG, and Masson trichrome staining) of abdominal aortas of PBS-injected (Vehicle) and IFN-γ-injected CD8 −/− mice after CaCl 2 aneurysm induction. Scale bar: upper layer 100 μm, lower layer 50 μm. B: Quantification of the collagen deposition area of the abdominal aortas (n = 5/group). C: Quantification of the elastin degradation score of the abdominal aortas (n = 6/group). D-F: Representative images of IFN-γ + /CD8a + T cell and MMP-2 + / and MMP-9 + /CD68 + macrophage in the adventitia of CD8 −/− AAA mice treated with PBS and IFN-γ (n = 5/group). Scale bar: 50 μm. L, lumen.

    Techniques Used: Staining, Injection



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    cd8a knockout (ko) mice  (Technology Development Co)
    90
    Technology Development Co cd8a knockout (ko) mice
    <t>CD8</t> + T-cell deletion mitigated the CaCl 2 -induced AAA formation and the investigated protein levels in aortic tissues. A,B: Representative photographs and data of the maximal external aortic diameter in CD8 +/+ and CD8 −/− mice treated with NaCl or CaCl 2 , respectively (n = 8/group). C–F: Representative western blotting images and quantitative data for the levels of NLRP3, caspase-1, gp91 phox , collagen I, and collagen III proteins in four experimental groups (n = 4/group). G,H: The ELISA results showing the serum levels of IFN-γ and IL-1β in the four groups (n = 6/group).
    Cd8a Knockout (Ko) Mice, supplied by Technology Development Co, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/cd8a knockout (ko) mice/product/Technology Development Co
    Average 90 stars, based on 1 article reviews
    cd8a knockout (ko) mice - by Bioz Stars, 2026-06
    90/100 stars
    		  Buy from Supplier

    Image Search Results


    CD8 + T-cell deletion mitigated the CaCl 2 -induced AAA formation and the investigated protein levels in aortic tissues. A,B: Representative photographs and data of the maximal external aortic diameter in CD8 +/+ and CD8 −/− mice treated with NaCl or CaCl 2 , respectively (n = 8/group). C–F: Representative western blotting images and quantitative data for the levels of NLRP3, caspase-1, gp91 phox , collagen I, and collagen III proteins in four experimental groups (n = 4/group). G,H: The ELISA results showing the serum levels of IFN-γ and IL-1β in the four groups (n = 6/group).

    Journal: Journal of Hypertension

    Article Title: CD8 + T-cell deficiency protects mice from abdominal aortic aneurysm formation in response to calcium chloride 2

    doi: 10.1097/HJH.0000000000003823

    Figure Lengend Snippet: CD8 + T-cell deletion mitigated the CaCl 2 -induced AAA formation and the investigated protein levels in aortic tissues. A,B: Representative photographs and data of the maximal external aortic diameter in CD8 +/+ and CD8 −/− mice treated with NaCl or CaCl 2 , respectively (n = 8/group). C–F: Representative western blotting images and quantitative data for the levels of NLRP3, caspase-1, gp91 phox , collagen I, and collagen III proteins in four experimental groups (n = 4/group). G,H: The ELISA results showing the serum levels of IFN-γ and IL-1β in the four groups (n = 6/group).

    Article Snippet: Male CD8 −/− (Cd8a knockout [KO]) and IFN-γ −/− (IFN-γ knockout [KO]) mice were purchased from Shanghai Biomodel Organism Science & Technology Development Co. (Shanghai, China; Protocol no. 2021-W5–2174) and were bred for the preparation of male CD8 −/− mice and male IFN-γ −/− of the same age.

    Techniques: Western Blot, Enzyme-linked Immunosorbent Assay

    CD8 + T-cell deficiency alleviated the histopathological changes and recruitment of inflammatory cells. A: The histopathological analysis (H&E, EVG, and Masson trichrome staining) of abdominal aortas of CD8 +/+ and CD8 −/− mice treated with NaCl or CaCl 2 , respectively. Scale bar: upper layer 100 μm, lower layer 50 μm. B: Quantification of the collagen deposition area of the abdominal aortas (n = 5/group). C: Quantification of the elastin degradation score of the abdominal aortas (n = 5/group). D-F: Representative images of IFN-γ + /CD8a + T cell and MMP-2 + / and MMP-9 + /CD68 + macrophage in the adventitia of CD8 +/+ and CD8 −/− AAA mice (n = 5/group). Scale bar: 50 μm. L, Lumen.

    Journal: Journal of Hypertension

    Article Title: CD8 + T-cell deficiency protects mice from abdominal aortic aneurysm formation in response to calcium chloride 2

    doi: 10.1097/HJH.0000000000003823

    Figure Lengend Snippet: CD8 + T-cell deficiency alleviated the histopathological changes and recruitment of inflammatory cells. A: The histopathological analysis (H&E, EVG, and Masson trichrome staining) of abdominal aortas of CD8 +/+ and CD8 −/− mice treated with NaCl or CaCl 2 , respectively. Scale bar: upper layer 100 μm, lower layer 50 μm. B: Quantification of the collagen deposition area of the abdominal aortas (n = 5/group). C: Quantification of the elastin degradation score of the abdominal aortas (n = 5/group). D-F: Representative images of IFN-γ + /CD8a + T cell and MMP-2 + / and MMP-9 + /CD68 + macrophage in the adventitia of CD8 +/+ and CD8 −/− AAA mice (n = 5/group). Scale bar: 50 μm. L, Lumen.

    Article Snippet: Male CD8 −/− (Cd8a knockout [KO]) and IFN-γ −/− (IFN-γ knockout [KO]) mice were purchased from Shanghai Biomodel Organism Science & Technology Development Co. (Shanghai, China; Protocol no. 2021-W5–2174) and were bred for the preparation of male CD8 −/− mice and male IFN-γ −/− of the same age.

    Techniques: Staining

    IFN-γ loading accelerated the CaCl 2 -induced AAA formation in the CD8 −/− mice. A,B: Representative photographs and quantitative data of the maximal external aortic diameter in the PBS-injected (Vehicle) or IFN-γ-injected CD8 −/− mice after CaCl 2 aneurysm induction (n = 8/group). C,D: Representative immunoblotting images and quantitative data for the levels of NLRP3, caspase-1, gp91 phox , collagen I, and collagen III proteins in the two groups (n = 3/group). E: The ELISA results showing the serum levels of IL-1β in both groups (n = 6/group).

    Journal: Journal of Hypertension

    Article Title: CD8 + T-cell deficiency protects mice from abdominal aortic aneurysm formation in response to calcium chloride 2

    doi: 10.1097/HJH.0000000000003823

    Figure Lengend Snippet: IFN-γ loading accelerated the CaCl 2 -induced AAA formation in the CD8 −/− mice. A,B: Representative photographs and quantitative data of the maximal external aortic diameter in the PBS-injected (Vehicle) or IFN-γ-injected CD8 −/− mice after CaCl 2 aneurysm induction (n = 8/group). C,D: Representative immunoblotting images and quantitative data for the levels of NLRP3, caspase-1, gp91 phox , collagen I, and collagen III proteins in the two groups (n = 3/group). E: The ELISA results showing the serum levels of IL-1β in both groups (n = 6/group).

    Article Snippet: Male CD8 −/− (Cd8a knockout [KO]) and IFN-γ −/− (IFN-γ knockout [KO]) mice were purchased from Shanghai Biomodel Organism Science & Technology Development Co. (Shanghai, China; Protocol no. 2021-W5–2174) and were bred for the preparation of male CD8 −/− mice and male IFN-γ −/− of the same age.

    Techniques: Injection, Western Blot, Enzyme-linked Immunosorbent Assay

    IFN-γ accelerated the histopathological changes and the recruitment of inflammatory cells in the CaCl 2 -induced AAAs in the CD8 −/− mice. A: The histopathological analysis (H&E, EVG, and Masson trichrome staining) of abdominal aortas of PBS-injected (Vehicle) and IFN-γ-injected CD8 −/− mice after CaCl 2 aneurysm induction. Scale bar: upper layer 100 μm, lower layer 50 μm. B: Quantification of the collagen deposition area of the abdominal aortas (n = 5/group). C: Quantification of the elastin degradation score of the abdominal aortas (n = 6/group). D-F: Representative images of IFN-γ + /CD8a + T cell and MMP-2 + / and MMP-9 + /CD68 + macrophage in the adventitia of CD8 −/− AAA mice treated with PBS and IFN-γ (n = 5/group). Scale bar: 50 μm. L, lumen.

    Journal: Journal of Hypertension

    Article Title: CD8 + T-cell deficiency protects mice from abdominal aortic aneurysm formation in response to calcium chloride 2

    doi: 10.1097/HJH.0000000000003823

    Figure Lengend Snippet: IFN-γ accelerated the histopathological changes and the recruitment of inflammatory cells in the CaCl 2 -induced AAAs in the CD8 −/− mice. A: The histopathological analysis (H&E, EVG, and Masson trichrome staining) of abdominal aortas of PBS-injected (Vehicle) and IFN-γ-injected CD8 −/− mice after CaCl 2 aneurysm induction. Scale bar: upper layer 100 μm, lower layer 50 μm. B: Quantification of the collagen deposition area of the abdominal aortas (n = 5/group). C: Quantification of the elastin degradation score of the abdominal aortas (n = 6/group). D-F: Representative images of IFN-γ + /CD8a + T cell and MMP-2 + / and MMP-9 + /CD68 + macrophage in the adventitia of CD8 −/− AAA mice treated with PBS and IFN-γ (n = 5/group). Scale bar: 50 μm. L, lumen.

    Article Snippet: Male CD8 −/− (Cd8a knockout [KO]) and IFN-γ −/− (IFN-γ knockout [KO]) mice were purchased from Shanghai Biomodel Organism Science & Technology Development Co. (Shanghai, China; Protocol no. 2021-W5–2174) and were bred for the preparation of male CD8 −/− mice and male IFN-γ −/− of the same age.

    Techniques: Staining, Injection